Coughlin Walter

Doing so may help facilitate the transition from traditional surgical dogma to evidence-based medicine in the operating room.Background Recent single-institution studies have shown that colorectal cancer (CRC) in patients 70 having a left-sided CRC ( less then 50 vs ≥ 70; OR = 2.8; 95% CI 2.7, 2.9). The incidence of CRC in those under 50 i…[Read more]

Bioactivation of the antidepressant and smoking cessation drug bupropion is catalyzed predominantly by cytochrome P4502B6 (CYP2B6). The metabolite hydroxybupropion derived from t-butylhydroxylation is considered to contribute to the antidepressant and smoking-cessation effects of the parent drug. Bupropion hydroxylation is the canonical in vitro…[Read more]